In-vitro Susceptibility to Aztreonam
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چکیده
Aztreonam is a new monobactam antibiotic which is highly active against aerobic Gram negative bacilli. The purpose of this study is to establish the in-vitro activity of aztreonam against recent clinical isolates of aerobic Gram negative bacilli obtained from patients at the Kuala Lumpur General Hospital. Minimum inhibitory concentrations of the antibiotic against the isolates were determined using an agar dilution method. Aztreonam was found to be active against a range of aerobic Gram negative bacilli including those which were resistant to gentamicin. There was however a significant incidence of resistance among Klebsiella sp and Salmonella sp. Aztreonam could be a valuable alternative in cases of infection due to gentamicin-resistant aerobic Gram negative bacilli.
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